VITAL METHYLATION
Nutrition Tips: Folic Acid: Killer or Cure-All?
https://www.huffpost.com/entry/nutrition-tips-folic-acid_b_601126_The author says Folic Acid is the killer, because it's artificial and unnatural, but Folate, with a similar but different chemistry, is natural and vital for health. He author says as follows.
_Unfortunately, science is never black and white and confusion is easy to come by -- even for trained scientists. (iii) The fortification of our food supply with folic acid in 1998 reduced spina bifida birth defects by 19 percent. A good thing. But by some estimates it may have caused an additional 15,000 cancers deaths a year. Oops. Now what?
_The answer is elemental. As in chemistry, biochemistry to be exact. It all comes down to this: Man-made molecules do funny, unpredictable things because they don't work with our normal biochemical pathways. Nature made molecules we have consumed for millennia work with our bodies.
_And therein lies the big problem with the nutrient known as B9. Folic acid, the molecule that is used to fortify our food supply, is used in most studies and in most vitamins. It is a man-made, funny looking molecule -- a fully oxidized, synthetic chemical compound that seems to cause all the mischief. It costs less and is more stable than the nature-made form of this nutrient.
_On the other hand, the nature-made form or forms, called "folates," do not seem to cause problems. This molecule is often found in foliage -- dark green leafy vegetables, hence the name folate. This can enter your normal biochemical pathways and gets properly metabolized. The folic acid may not be converted or metabolized by the body, increasing cancer and disease risk. The excess folic acid becomes oxidized and promotes free radical production and genetic instability leading to cancer and other disease.
… The good news is that you can take the nature-made form of this nutrient -- called methyl folate (and there are a few forms of that too). This is what should be in food and vitamin supplements. Many conscientious companies are now using only this form of the nutrient, but it is more expensive.
_Here's what you should do:
Don't eat fortified foods! If it needs to be fortified with folic acid, that is because it has been impoverished and refined in the first place (think white flour, white rice, cereals and processed foods). Just eat real, whole fresh food!
_Look at your supplement label! If it says "folic acid" then find another vitamin that has the words "L 5 methyl-tetrahydrofolate" or "5 formyl tetrahydrofolate" on the label.
_Now for those who want to know a little bit more about the reason why folate and its companions B6 and B12 are the most critical and health promoting hit parades in the nutrient world.
_The Secret of Folate: The Magic of Methylation
_Taking just a few vitamins CAN optimize the function of ALL your body's systems. It's true. But you have to know what to take, what form of the nutrients and you have to know why these supplements work ...
_In this blog, I am going to discuss one of the most important biochemical processes for long-term health and how to keep it functioning optimally with supplements and other strategies. This process is called methylation because it involves moving around a chemical group called methyl, which consists of one carbon and three hydrogen molecules.
_Unfortunately, many people suffer from one or more of the eight factors that negatively impact this biochemical process, so problems in this area are widespread, though many don't realize they are suffering.
_However, there are MANY things that you can do to optimize this critical biochemical process that may have a dramatic impact on your health. In today's blog I will review the eight factors that can lead to problems in this area, and outline 12 tips that will help you optimize this essential part of your biology.
… Methylation is a key biochemical process that is essential for the proper function of almost all of your body's systems. It occurs billions of times every second; it helps repair your DNA on a daily basis; it controls which genes are turned on or turned off; it controls homocysteine (an unhealthy compound that can damage blood vessels); it helps recycle molecules needed for detoxification; and it helps maintain mood and keep inflammation in check.
_To keep methylation running smoothly you need optimal levels of B vitamins. Without enough B vitamins methylation breaks down, and the results can be catastrophic. In these cases we see more birth defects like spina bifida, more cases of Down's syndrome, and more miscarriage.
A breakdown in methylation also puts you at higher risk for conditions like osteoporosis, diabetes, cervical dysplasia and cancer, colon cancer, lung cancer, depression, pediatric cognitive dysfunction (mood and other behavioral disorders), dementia, and stroke. And like Mr. Roberts and Mr. McNally, you may be at higher risk for cardiovascular disease.
_To avoid all of these problems, the key is to optimize methylation. That means avoiding the things that cause your methylation to break down, testing to find out how well your methylation is working and including the things that support proper methylation. Let's look at how to do that.
_8 Factors that Affect Your Methylation Process
_Eight major factors negatively impact methylation. They are:
1. Genetics. Like an estimated 20-30 percent of us, you could be genetically predisposed to high homocysteine.
2. Poor diet. The word "folate" comes from "foliage." You need to eat plenty of leafy greens, beans, fruit, and whole grains to get adequate levels of vitamins B6 and B12, betaine and folate (all in the right nature made forms). Egg yolks, meat, liver and oily fish are the main dietary sources of vitamin B12 -- so long-term vegan diets can be a problem. Plus, certain compounds can raise levels of homocysteine and deplete the B vitamins. These include excess animal protein, sugar, saturated fat, coffee and alcohol. Irradiation of food depletes nutrients, so foods treated this way may be lower in B vitamins, too.
3. Smoking. The carbon monoxide from cigarette smoke inactivates vitamin B6.
4. Malabsorption. Conditions like digestive diseases, food allergies, and even aging can reduce absorption of nutrients.
5. Decreased stomach acid. Aging and other conditions can reduce stomach acid -- and therefore absorption of vitamin B12.
6. Medications. Drugs like acid blockers, methotrexate (for cancer and arthritis and other autoimmune diseases), oral contraceptives, HCTZ or hydrochlorthiazide (for high blood pressure) and Dilantin (for seizures) can all affect levels of B vitamins.
7. Other conditions. These include hypothyroidism, kidney failure or having only one kidney, cancer and pregnancy.
8. Toxic exposures. Some toxins such as mercury can interfere with vitamin production.
Watch out for these factors and you will go a long way toward protecting your methylation.
_Measuring Your Own Methylation Process
To find out if your methylation process is optimal, ask your doctor for the following tests:
1. Complete blood count. … Large red blood cells or anemia can be a sign of poor methylation. Red blood cells with a mean corpuscular volume (MCV) greater than 95 can signal a methylation problem.
2. Homocysteine. This is one of the most important tests you can ask for. The normal level is less than 13, but the ideal level is likely between six and eight.
3. Serum or urinary methylmalonic acid. This is a more specific test for vitamin B12 insufficiency. Your levels may be elevated even if you have a normal serum vitamin B12 or homocysteine level.
4. Specific urinary amino and organic acids. These can be used to look for unusual metabolism disorders involving vitamins B6 or B12 or folate, which may not show up just by checking methylmalonic acid or homocysteine.
_12 Tips to Optimize Your Methylation Process
_Just as there are many causes of poor methylation, there are lots of things that support its proper functioning. Here's how to optimize methylation and prevent conditions like heart disease, cancer, dementia, depression and more.
1. Eat more dark, leafy greens. You want to eat l cup a day of vegetables like bok choy, escarole, Swiss chard, kale, watercress, spinach, dandelion, mustard, collard or beet greens. These are among the most abundant sources of the nutrients needed for optimal methylation. You can't get too much folate from food.
2. Get more Bs in your diet. Good food sources include sunflower seeds and wheat germ (vitamin B6), fish and eggs (vitamin B6 and B12), cheese (B12), beans and walnuts (vitamin B6 and folate), leafy dark green vegetables, asparagus, almonds, whole grains (folate) and liver (all three).
3. Minimize animal protein, sugar and saturated fat. Animal protein directly increases homocysteine. Sugar and saturated fat deplete your body's vitamin stores.
4. Avoid processed or refined foods and canned foods. These are depleted in vitamins.
5. Avoid caffeine. Excess amounts can deplete your B vitamin levels.
6. Limit alcohol to three drinks a week. More than this can deplete your B vitamin levels.
7. Don't smoke. As noted above, smoking inactivates vitamin B6.
8. Avoid medications that interfere with methylation. See notes on this above.
9. Keep the bacteria in your gut healthy. Take probiotic supplements and use other measures to make sure the bacteria in your gut are healthy so you can properly absorb the vitamins you do get.
10. Improve stomach acid. Use herbal digestives (bitters) or taking supplemental HCl.
11. Take supplements that prevent damage from homocysteine. Antioxidants protect you from homocysteine damage. Also make sure you support methylation with supplements like magnesium and zinc.
12. Supplement to help support proper homocysteine metabolism. Talk to your doctor to determine the best doses and forms for you. Here are a few suggestions:
• Folates: Amounts can vary based on individual needs from 200 mcg to one mg. Some people may also need to take preformed folate (folinic acid or five formylTHF, or five methyl folates) to bypass some of the steps in activating folic acid.
• Vitamin B6: Take two to five mg a day. Some people may need up to 250 mg or even special "active" B6 (pyridoxyl-5-phosphate) to achieve the greatest effect. Doses higher than 500 mg may cause nerve injury.
• Vitamin B12: Doses of 500 mcg may be needed to protect against heart disease. Oral vitamin B12 isn't well absorbed; you may need up to 1 or 2 mg daily. Ask your doctor about B12 shots or doses you can take under the tongue.
• Betaine: This amino acid derivative is needed in doses from 500 to 3,000 mg a day, depending on the person.
_By working to optimize your methylation you can protect yourself from virtually all the so called "diseases of aging." When you do, you will be well on the road to lifelong vibrant health.
_Mark Hyman, M.D.
_References
(i) Jaszewski R, Misra S, Tobi M, Ullah N, Naumoff JA, Kucuk O, Levi E, Axelrod BN, Patel BB, Majumdar AP. Folic acid supplementation inhibits recurrence of colorectal adenomas: a randomized chemoprevention trial. World J Gastroenterol. 2008 Jul 28;14(28):4492-8.
(ii) Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, McKeown-Eyssen G, Summers RW, Rothstein RI, Burke CA, Snover DC, Church TR, Allen JI, Robertson DJ, Beck GJ, Bond JH, Byers T, Mandel JS, Mott LA, Pearson LH, Barry EL, Rees JR, Marcon N, Saibil F, Ueland PM, Greenberg ER; Polyp Prevention Study Group. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007 Jun 6;297(21):2351-9.
(iii) Bland J. Systems biology, functional medicine, and folates. Altern Ther Health Med. 2008 May-Jun;14(3):18-20. Review.
(iv) Lightfoot TJ, Barrett JH, Bishop T, Northwood EL, Smith G, Wilkie MJ, Steele RJ, Carey FA, Key TJ, Wolf R, Forman D. Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2421-30.
_Mark Hyman, M.D. practicing physician and founder of The UltraWellness Center is a pioneer in functional medicine. Dr. Hyman is now sharing the 7 ways to tap into your body's natural ability to heal itself.