First Top Priority: Earthing, Sunshine, and Negative Ion Air from Trees/ShrubsSecond Top Priority: Natural Vitamin C and Vitamin B5(1 Amla capsule half hour before 1st meal & 1 Vitamin C tablet half hour before second meal & 100mg Vitamin B5/da with meal -- Both to restore the Adrenals for stress & immunity; Vitamin C to strengthen Blood Vessels to protect from heart attack & stroke.)
A good source of vitamin C and B5 etc ordering online is
http://VitaCost.com This link is apparently their best deal for vitamin C from Amla Berries:
https://www.vitacost.com/solaray-amla-extract-500-mg-60-vegetarian-capsulesThis seems to be the best deal for B5:
https://www.vitacost.com/solaray-pantothenic-acid-250-mg-100-capsulesThere's also a cheap source of Vitamin C tablets there.
James Sloane, a former med tech, found that in medical studies vitamin C and B5 are important for adrenal gland function, but synthetic ascorbic acid vitamin C is short-lived, while natural vitamin C in foods, is stable (if it's not heated). Vitamin C is also important for all blood vessels, but the body prioritizes the adrenals [to handle stress and help the immune system]. Stress depletes C and B5, but a few hundred mg per day of vitamin C, half hour before meals (to prevent absorption being blocked by protein and fat digestion), is enough to restore it and about 100 mg of B5 per day (with meals) is enough. This will allow extra C to go to blood vessels to maintain them. [Rice bran is better for all the B vitamins.]
2nd Priority: Magnesium Malate capsules (or Magnesium Citrate) & Lecithin granules (Magnesium 400mg/da half hour before meal to soften plaque {& prevent Muscle cramps}; Lecithin 1T/meal to remove plaque from Blood Vessels {& improve mood})
3rd Priority: Zinc capsules & Rice Bran(Zinc 25mg/da with meal for immune system & digestive system & Rice Bran 1T/meal for digestive system & to feed microflora, another part of the immune system.)
4th Priority: Silica(Silica from Diatomaceous Earth 1 or 2T in quart jar or gallon jar or pot filled with water; Silica dissolves into the water as orthosilicic acid, the form the body uses, about 1mg/cup of water; Drink 6 to 8 cups/da; Fill container with water after drinking each cupful; to strengthen bones & improve skin.)
5th Priority: Licorice Root powder or Yucca Root powder(1 or 2tsp/da to prevent or reduce inflammation)
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EXCERPTS FROM VITAMIN C STUDIESVitamin C prevents oxidative damage
https://www.ncbi.nlm.nih.gov/pubmed/8885335The observations substantiate the previous in vitro findings that ascorbate specifically prevents oxidative degradation of microsomal membranes. The results indicate that vitamin C may exert a powerful protection against degenerative diseases associated with oxidative damage and play a critical role in wellness and health maintenance.
Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla
https://www.ncbi.nlm.nih.gov/pubmed/15666839The data derived from these animal models and various cell culture studies confirm a crucial role for vitamin C for both the adrenal cortex as well as the adrenal medulla further underlining the interdependence of the two endocrine systems united in one gland.
The role of functional foods in the psychobiology of health and disease
https://www.ncbi.nlm.nih.gov/pubmed/19079896Presently there are a number of ingredients, which include vitamin C, milk proteins, a number of herbal extracts (ginkgo biloba, ginseng, kava, valerian and lemon balm), and n-3 fatty acids, that have demonstrated potential stress reactivity-lowering and mood-enhancing effects, although further work is required to substantiate the efficacy in human subjects. Dietary supplements that can alleviate excessive stress responses may play an increasingly important role for the maintenance of health in a stressful environment.
Vitamin C in the treatment and/or prevention of obesity
https://www.ncbi.nlm.nih.gov/pubmed/25866299Obesity has emerged as one of the major health threats worldwide. Moreover, an excessive body fat accumulation, which defines this disease, could lead to several associated clinical manifestations such as cardiovascular events, type 2 diabetes, inflammation, and some types of cancer. The appearance of these co-morbidities has been often related to an unbalanced oxidative stress. Therefore, antioxidant-based treatments could be considered as interesting approaches to possibly counteract obesity fat accumulation complications. In this context, it has been observed that vitamin C intake (ascorbic acid) is negatively associated with the occurrence of several conditions such as hypertension, gallbladder disease, stroke, cancers, and atherosclerosis, and also with the onset of obesity in humans and animals. Among the possible beneficial effects of ascorbic acid on obesity-related mechanisms, it has been suggested that this vitamin may: (a) modulate adipocyte lipolysis; (b) regulate the glucocorticoid release from adrenal glands; (c) inhibit glucose metabolism and leptin secretion on isolated adipocytes; (d) lead to an improvement in hyperglycemia and decrease glycosylation in obese-diabetic models; and (e) reduce the inflammatory response. Possibly, all these features could be related with the outstanding antioxidant characteristics of this vitamin. Thus, the present article reviews the up-to-date evidence regarding in vitro and in vivo effects of vitamin C in obesity and its co-morbidities.
Treatment of the common cold in children and adults
https://www.ncbi.nlm.nih.gov/pubmed/22962927Prophylactic vitamin C modestly reduces cold symptom duration in adults and children.
Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2
https://www.ncbi.nlm.nih.gov/pubmed/19162177Neurodegenerative diseases typically involve high levels of oxidative stress and thus ascorbate has been posited to have potential therapeutic roles against ischemic stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone
https://www.ncbi.nlm.nih.gov/pubmed/17616774CONCLUSIONS: Adrenocorticotrophic hormone stimulation increases adrenal vein but not peripheral vein vitamin C concentrations. These data are the first in humans showing that hormone-regulated vitamin secretion occurs and that adrenal vitamin C paracrine secretion is part of the stress response. Tight control of peripheral vitamin C concentration is permissive of higher local concentrations that may have paracrine functions.
Pantothenic acid deficiency as a factor contributing to the development of hypertension
https://www.ncbi.nlm.nih.gov/pubmed/4053129In this paper, pantothenic acid deficiency will be shown to be a factor in the experimental origin of hypertension due to adrenal regeneration [or degeneration?].
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Stability of vitamin C (ascorbic acid) in tablets
First published: July 1976
http://onlinelibrary.wiley.com/doi/10.1002/jps.2600650704/abstract_Stability of ascorbic acid (vitamin C) in various tablet formulations and the nature and extent of formation of decomposition products (dehydroascorbic acid, diketogulonic acid, and oxalic acid) were determined under normal conditions of storage and in simulated use tests. IR spectrophotometric, colorimetric, fluorometric, titrimetric, polarographic, and chromatographic methods were applied. Recent implications concerning the instability of ascorbic acid in tablets and the potentially harmful nature of the breakdown products are shown to be unfounded. Under normal storage conditions, commercial-type ascorbic acid tablets are stable for over 5 years (>95% potency retention). The amounts of all three breakdown products formed under the various storage conditions constitute a small percentage of the ascorbic acid content and pose no dietary hazard. IR spectroscopy was inadequate as a quantitative method for evaluating ascorbic acid potency in tablet formulations. The official titration methods and TLC, colorimetric, and polarographic determinations correlate well and define accurately the stability of ascorbic acid in these dosage forms.
Elevated temperature studies on stability of ascorbic acid in certain fruit juice and aqueous vehicles
First published: October 1964
http://onlinelibrary.wiley.com/doi/10.1002/jps.2600531029/abstract_The stability of ascorbic acid was investigated in certain fruit juice and aqueous vehicles between pH 2.5–6.5 at 37 and 55° in the presence of 0.2 per cent citric acid, 0.01 per cent EDTA, 0.01 per cent propyl gallate, 0.2 per cent ferrous gluconate, 0.2 per cent cysteine hydrochloride, and 0.2 per cent potassium m-bisulfite. Lime juice—sorbitol—glycerol (2:2:1) retained 70 per cent ascorbic acid at pH 6.5 after 120 days. Citric acid also protected ascorbic acid. EDTA gave little protection to ascorbic acid. The loss of ascorbic acid in aqueous solution at some pH values was counteracted by 0.9 per cent sodium chloride. Dihydrosteptomycin sulfate in the concentration of 0.33 mg./ml. gave protection to ascorbic acid at all pH levels, except at pH 6.5 (37°) and at pH 5.5 (55°), where a destructive effect was noticed. Stability of ascorbic acid was a function of pH, temperature, vehicle, and head space in the container.
EFFECT OF STORAGE CONDITIONS ON THE STABILITY OF ASCORBIC ACID IN SOME FORMULATIONS
Vol 8, Issue 4, 2016
https://innovareacademics.in/journals/index.php/ijap/article/view/14131_Objective: The stability of ascorbic acid is affected by temperature, pH, sunlight and the presence of metals like copper and iron.
_The study seeks to investigate the effect of storage conditions on the stability of ascorbic acid in tablets (buccal tablets) and syrups sampled from the Ghanaian market.
_Methods: Ascorbic acid tablets were sampled and stored separately at room temperature and under refrigeration (in a fridge) and assayed periodically for 35 d. Ascorbic acid syrups were also sampled and stored at room temperature, in a bowl of water and under refrigeration and also assayed periodically for 35 d. The mode of assay was iodimetry.
_Results: For both formulations, storage under refrigeration saw the least breakdown and at room temperature, the breakdown of ascorbic acid was greatest. The syrups stored in a bowl of water were more stable than those stored at room temperature. The % breakdown of ascorbic acid in the syrups and tablets stored at room temperature were statistically significant in comparison to that under refrigeration as determined by a T-test. The % breakdown of ascorbic acid in the syrups stored in a bowl of water was not statistically significant in comparison to that under refrigeration.
_Conclusion: Ascorbic acid formulations should be stored under refrigeration or at low temperatures if possible. In the absence of refrigeration, patients should be advised to store syrups of ascorbic acid in a bowl of water and the tablets at cool places in homes.
Stability of ascorbic acid in commercially available orange juices
Published - 2002
https://asu.pure.elsevier.com/en/publications/stability-of-ascorbic-acid-in-commercially-available-orange-juice_Results: The orange juices from frozen concentrates contained 86 mg reduced vitamin C per fluid cup at initial preparation and 39 to 46 mg/c after 4 weeks of storage. Ready-to-drink juices averaged significantly lower reduced vitamin C: 27 to 65 mg/c at opening and 0 to 25 mg/c at expiration 4 weeks later. Ready-to-drink orange juices had twofold to threefold higher concentrations of oxidized vitamin C vs the orange juices reconstituted from frozen, and the decomposition rate of reduced vitamin C was similar for all juices, about 2% per day once opened. Applications: Ready-to-drink orange juices should be purchased 3 to 4 weeks before expiration date and consumed within 1 week of opening.
The stabilization of L-ascorbic acid in aqueous solution and water-in-oil-in-water double emulsion by controlling pH and electrolyte concentration
Cosmet. Sci., 55, 1-12 (January/February 2004) September 11, 2003
_Synopsis. This study presents a new approach that can stabilize effectively L-ascorbic acid in water-in-oil-in-water (w/o/w) double emulsions. Basically, the behavior of L-ascorbic acid in the aqueous phase was observed, considering its molecular deformation. Then, it was found that the stability determined in the aqueous phase by high-performance liquid chromatography (HPLC) showed that the collapse of ionization of L-ascorbic acid played a crucial role in protecting the molecular deformation. Then, the stable aqueous system was incorporated into the internal aqueous phase of the double emulsions. From the HPLC analysis, it was observed that the L-ascorbic acid in an appropriate system showed high molecular stability for a long time. Moreover, in the measurement of in vitro skin permeation, the L-ascorbic acid stabilized in this study showed considerable skin permeation ability, indicating its potential applicability in pharmaceutics and cosmetics.
Why does the stability of ascorbic acid decrease (increased rate of oxidation to dehydroascorbic acid) when pH increases?
https://chemistry.stackexchange.com/questions/74202/why-does-the-stability-of-ascorbic-acid-decrease-increased-rate-of-oxidation-to_The decrease of ascorbic acid is probably mostly due to oxidation. Oxidation is loss of electrons. Increased pH means more ascorbate, thus negative charge and higher electron density. Higher electron density means easier loss of electrons, thus more oxidation and less ascorbic acid at the end.
The high ascorbic acid content is the main cause of the low stability of anthocyanin extracts from acerola - 2007
https://www.e-science.unicamp.br/quimifea/admin/publicacoes/documentos/publicacao_610_De%20Rosso%202007%20-%20acido%20ascorbico.pdfIn summary, the results of the present study prove that the presence of elevated concentrations of ascorbic acid is the main cause of the low stability of the acerola anthocyanins, which occurs mainly due to the direct condensation of the AA on carbon 4 of the anthocyanin, resulting in losses of both components. Anthocyanin degradation is responsible for the loss in red colour of the frozen acerola pulp and processed juice, the main problem occurring during the commercial storage of these products
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